个人简介

李春美，中共党员，女，1973年生，澳门十大正规网投平台三级岗教授，博士，博士生导师。澳门十大正规网投平台食品化学系主任。获得“教育部新世纪优秀人才”、“ 湖北省杰出青年基金”、获得“澳门十大正规网投平台教学质量优秀一等奖””，“学院研究生导师教书育人奖”，“澳门十大正规网投平台先进女教职工”等荣誉称号；多次被评为澳门十大正规网投平台“优秀共产党员”。

教育经历

1991/09-1995/06：澳门十大正规网投平台食品科学专业，学士。
1995/09-2000/06：澳门十大正规网投平台农产品加工及贮藏工程专业，博士。

工作经历

2000/07-2002/12：澳门十大正规网投平台，讲师。
2003/01-2010/12：澳门十大正规网投平台，副教授。
2009/05-2010/05：美国Miami University，访问学者
2010/12-至今：澳门十大正规网投平台，教授/博导。
2018/01-2018/03：美国罗格斯大学（Rutgers University），高级访问学者

研究领域

一直致力于植物多酚的研究，研究方向稳定。围绕与植物多酚相关的农产品的采后加工难点，以富含多酚的柿子、茶等为对象，重点针对其加工与高值利用过程中关键性技术难点所涉及的化学结构、活性变化及机制等展开深入研究。主要研究方向有：1.植物多酚提取分离新技术，结构分析，健康调节作用及其分子机制。2. 特色果蔬以及林果的褐变控制以及精深加工及其高值高效利用新技术研究。3. 植物多酚通过与食品成分互作抑制加工过程中有毒有害产物如杂环胺、丙烯酰胺、晚期糖基化产物等形成的作用及机制。

科研项目

（一）入选的人才计划项目：
1. 教育部新世纪优秀人支持计划，NCET-12-0865，“柿子单宁对非酒精性脂肪肝脂质代谢影响机制研究”，2013.1-2015.12，50万元，主持。
2. 湖北省杰出青年基金,2011CDA108 ,“柿子单宁与其特异靶标蛇毒磷脂酶A2的结合作用及机制”，2012.1-2013.12，10万元，主持。
3. 武汉市青年科技晨光计划，20065004116-24 ，“莲藕色素前体物质与PPO超分子相互作用及其对莲藕褐变的影响”，2006.1-2008.12， 4.5万元，主持。
4. 瑞典国际科学基金（IFS），E/3657-1, “Study on the influence of oxidation of tea catechins on the flavor of green tea beverages during a long shelf life”IFS， 2004.1-2005.12，8000美元，主持。
（二）主持的其它科研项目
1.国家重点研发计划“特色经济林优异种质发掘和精细评价”，2019YFD1000603-1，138万，子课题主持，2019.5-2-2022.12。
2.国家重点研发计划“特色经济林采后果实与副产物增值加工关键技术研究”，2019YFD1002304，135万，子课题主持，2020.1-2022.12。
3.中央高校基本科研业务费专项资金“基于脂质筏结构破坏和IR结合的柿ECG二聚体抑制脂肪细胞分化的分子机制”，2018.1-2020.12, 24万元，主持。
4. 国家自然科学基金面上项目， 31571839 “柿稀有原花青素二聚体通过脂质筏及其上特异受体67LR抑制3T3-L1前脂肪细胞分化的分子机制”，81万元，2016.1-2019.12，主持
5. 国家自然科学基金面上项目，31271833 “DP9柿子单宁对其靶标蛋白蛇毒PLA2的特异识别及共价修饰位点研究”，2013.1-2016.12，80万元，主持。
6. 公益性行业（农业）科研专项经费子课题, 201203047-01,“现代柿产业关键技术研究与试验示范”，2013.1-2016.12，50万元，主持 7. 武汉市科技攻关项目，20130205010186，“柿子低温喷雾干燥新技术及系列产品开发”, 2013.1-2014.12，15万元，主持。
8. 中央高校基本科研业务费专项资金“应季与反季节番茄主要营养、特征风味及代表性活性成分的环境调控研究”，2013-2015,40万元，主持。 9. 国家“十二五”科技支撑计划“南方特色果蔬食品加工关键技术研究”（子课题）,2012-2015,10万元，已结题，主持。
10.中央高校基本科研业务费专项资金“柿单宁及其特征结构单元对其特异靶标蛇毒磷脂酶A2结构修饰机制”，2011PY119，2011-2013，15万元，主持
11 国家自然科学基金面上项目，30972398，“柿子提取物解蛇毒关键级分的结构表征及作用机理研究”；2010.1-2012.12，30万，主持。
12. 教育部科学技术研究重点项目，No.109115，“柿子单宁解蛇毒作用及其构效关系研究”, 2009.1-2011.12，10万元，主持。
13. 湖北省重大科技攻关计划，2007AA204A01，“淡水鱼蛋白功能食品及废弃物的高效利用技术研究”, 2007.1-2008.12，90万元，主持。

成果奖励

【代表性论文】
1. Wei Zhu, Yangyang Jia, Jinming Peng, and Chun-mei Li*, Inhibitory Effect of Persimmon Tannin on Pancreatic Lipase and the Underlying Mechanism in Vitro.Journal of Agricultural and Food Chemistry, 2018，DOI: 10.1021/acs.jafc.8b00850
2. Wei Zhu, Kuan Lin, Kaikai Li, Xiangyi Deng and Chunmei Li *.Reshaped fecal gut microbiota composition by theintake of high molecular weight persimmon tannin in normal and high-cholesterol diet-fed rats. Food&Function., 2018, 9, 541–551
3.Ibrahim Khalifa, Wei Zhu, Kaikai Lia, Chunmei Li*. Polyphenols of mulberry fruits as multifaceted compounds: Compositions, metabolism, health benefits, and stability—A structural review[J]. Journal of Functional Foods, 2018, 40(1):28-43.
4.Torkun Mamet, Zhenzhen Ge, Ying Zhang,Chunmei Li*.Interactions between highly galloylated persimmon tannins and pectins[J]. International Journal of Biological Macromolecules, 2018,106:410-417.
5. Ibrahim Khalifa, Rongzu Nie, Zhenzhen Ge, Kaikai Li, Chunmei Li*. Understanding the shielding effects of whey protein on mulberryanthocyanins: Insights from multispectral and molecularmodelling investigations. International Journal of Biological Macromolecules, 2018, doi:10.1016/j.ijbiomac.2018.07.117
6. Jinming Peng, Kaikai Li, Wei Zhu, Xiangyi Deng, Chunmei Li*. Separation and purification of four phenolic compounds from persimmon by high-speed counter-current chromatography[J]. Journal of Chromatography B, 2018, 1072:78-85.
7. Zhenzhen Ge, Mengying Zhang, Xiangyi Deng, Wei Zhu, Kaikai Li, Chunmei Li*. Persimmon tannin promoted macrophage reverse cholesterol transport through inhibiting ERK1/2 and activating PPARγ both in vitro and in vivo[J]. Journal of Functional Foods, 2017, 38:338-348.
8. Wei Zhu ,Xiangyi Deng,Jinming Peng,Bo Zou,Chunmei Li*. A-type ECG and EGCG dimers inhibit 3T3-L1 differentiation by binding to cholesterol in lipid rafts[J]. Journal of Nutritional Biochemistry, 2017, 48:62-73.
9. Rongzu Nie, Wei Zhu, Jinming Peng, Zhenzhen Ge, Chunmei Li*. Comparison of disaggregative effect of A-type EGCG dimer and EGCG monomer on the preformed bovine insulin amyloid fibrils[J]. Biophysical Chemistry, 2017, 230:1-9.
10. Torkun Mamet, Fen Yao, Kaikai Li,Chunmei Li*.Persimmon tannins enhance the gel properties of high and low methoxyl pectin[J].LWT - Food Science and Technology, 2017,86:594-602.
11. Ying Zhang,Chunmei Li*. The detoxifying effects of structural elements of persimmon tannin on Chinese cobra phospholipase A2 correlated with their structural disturbing effects well[J]. Journal of Food & Drug Analysis, 2017, 25:731-740.
12. Tao Liu, Wei Zhu, Jing Huang, Huahan Chen, Rongzu Nie, Chunmei Li*.Comparison of the nutritional as well as the volatile compositionof in‑season and off‑season Hezuo 903 tomato at red stage. Eur Food Res Technol,2017, 243:203–214
13. Wei Zhu,Le Xiong, Jinming Peng,Xiangyi Deng,Jun Gao,and Chunmei Li*. Structure-dependent membrane perturbing potency of four proanthocyanidin dimers on 3T3-L1 preadipocytes[J]. Journal of Agricultural & Food Chemistry, 2016, 64(37)：7022-7032.
14. Zhenzhen Ge, Wei Zhu, Jinming Peng,Xiangyi Deng,Chunmei Li*. Persimmon tannin regulates the expression of genes critical for cholesterol absorption and cholesterol efflux by LXRα independent pathway[J]. Journal of Functional Foods, 2016, 23:283-293.
15. Jinyu Chen, Ze Xu, Wei Zhu, Rongzu Nie, Chunmei Li *.Novel proanthocyanidin dimer analogues with the C-ring-opened diaryl-propan-2-gallate structural unit and enhanced antioxidant activities[J]. Journal of Functional Foods, 2016, 21:290-300.
16. Zhenzhen Ge,Rongzu Nie,Tuoerkun Maimaiti, Fen Yao,Chunmei Li*. Comparison of the inhibition on cellular 22-NBD-cholesterol accumulation and transportation of monomeric catechins and their corresponding A-type dimers in Caco-2 cell monolayers[J]. Journal of Functional Foods, 2016, 27:343-351.
17. Wei Zhu,Le Xiong, Jinming Peng,Xiangyi Deng,Jun Gao,and Chunmei Li*. Molecular Insight into Affinities of Gallated and Nongallated Proanthocyanidins Dimers to Lipid Bilayers[J]. Sci Rep, 2016, 6:37680.
18. Wei Zhu, Ibrahim Khalifa, Jinming Peng and Chunmei Li*. Position and orientation of gallated proanthocyanidins in lipid bilayer membranes: influence of polymerization degree and linkage type，Journal of Biomolecular Structure & Dynamics, 2017:1-14
19. Rongzu Nie, Wei Zhu, Jinming Peng,Zhenzhen Ge,Chunmei Li*. A-type dimeric epigallocatechin-3-gallate (EGCG) is a more potent inhibitor against the formation of insulin amyloid fibril than EGCG monomer[J]. Biochimie, 2016, 125:204-212.
20. Zhen-zhen Ge, Xiao-qian Dong, Wei Zhu, Ying Zhang, and Chun-mei Li*.Metabolites and Changes in Antioxidant Activity of A-Type andB-Type Proanthocyanidin Dimers after Incubation with Rat IntestinalMicrobiota[J]. Journal of Agricultural and Food Chemistry, 2015,63(41): 8991–8998
21. Wei Zhu，Bo Zou，Rongzu Nie，Ying Zhang，Chun-mei Li*. A-type ECG and EGCG dimers disturb the structure of 3T3-L1 cell membrane and strongly inhibit its differentiation by targeting peroxisome proliferator-activated receptor γ with miR-27 involved mechanism[J]. The Journal of Nutritional Biochemistry. 2015, 26(11):1124–1135
22. Jinyu Chen, Yujuan Xu, Zhenzhen Ge,Wei Zhu, Ze Xu,Chunmei Li*. Structural elucidation and antioxidant activity evaluation of key phenolic compounds isolated from longan (Dimocarpus longan, Lour.) seeds[J]. Journal of Functional Foods, 2015, 17(4):872-880.
23. Jinyu Chen, Zhen-zhen Ge, Wei Zhu, Ze Xu, and Chunmei Li*. Screening of Key Antioxidant Compounds of Longan (Dimocarpuslongan Lour.) Seed Extract by Combining Online Fishing/Knockout,Activity Evaluation, Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, and High-Performance Liquid ChromatographyElectrospray Ionization Mass Spectrometry Methods.Journal of Agricultural and Food Chemistry,2014, 62, 9744−9750
24. Bo Zou,Rongzu Nie,Jian Zeng,Zhen-zhenGe,Ze Xu,ChunmeiLi*.Persimmon tannin alleviates hepatic steatosis in L02 cells by targeting miR-122 and miR-33b and its effects closely associated with the A type ECG dimer and EGCG dimer structural units[J]. Journal of Functional Food, 2014, 11:330-341
25. Bo Zou, Zhenzhen Ge, Wei Zhu, Ze Xu, Chunmei Li*. Persimmon tannin represses 3T3-L1 preadipocyte differentiation via up-regulating expression of miR-27and down-regulating expression of peroxisome proliferator-activated receptor γin the early phase of adipogenesis[J]. European Journal of Nutrition. 2014,54(8):1333-1343
26. Jinyu Chen, Jing Du, Zhen-zhen Ge, Wei Zhu, Rongzu Nie, Chun-mei Li*. Comparison of sensory and compositions of five selected persimmon cultivars (Diospyros kaki L.) and correlations between chemical components and processing characteristics[J]. J Food Sci Technol, 2016, 53(3):1597-1607
27. Zou Bo, Ge Zhen-zhen, Zhang Ying, Du jing, Xu Ze,Li Chun-mei*.Persimmon Tannin accounts for the anti-hyperlipidemic effects of persimmon through activating of AMPK and suppressing NF-κB activation and inflammatory responses in High-Fat Diet Rats[J]. Food and Function, 2014, 5:1536-1546
28. Du jing, Ge Zhen-zhen, Xu Ze, Zou Bo, Zhang Ying,Li Chun-mei*. Comparison of the efficiency of five different drying carriers on the spray drying of persimmon pulp powders[J]. Drying Technology. 2014, 32: 1157–1166
29. Bo Zou , Xiao-qianDong, Zhen-zhen Ge, Ze Xu, Jing Du, Chun-mei Li *. Development of suitable standards for quantitative determination of persimmon phenol contents in Folin‑Ciocalteu and vanillin assays[J]. Eur Food Res Technol (2014) 239:385–391
30. Xu Ze, Wei Le-hong, Ge Zhen-zhen, Zhu Wei, Li Chun-mei*.Comparison of the degradation kinetics of A-type and B-type proanthocyanidins dimers as a function of pH and temperature[J]. Eur Food Res Technol. 2014 ,240(4):707-717
31. Chun-mei Li*, Ying Zhang , Jie Yang, Bo Zou, Xiao-qian Dong,Ann E. Hagerman. The interaction of a polymeric persimmon proanthocyanidinfraction with Chinese cobra PLA2 and BSA[J]. Toxicon. 2013,67:71–79
32. Ying Zhang, Li Zhong, Bin Zhou, Jin-yu Chen, Chun-mei Li*. Interaction of characteristic structural elements ofpersimmon tannin with Chinese cobra PLA2[J]. Toxicon. 2013，74:34–43
33. DongXiao-qian, ZouBo, ZhangYing, GeZhen-zhen, DuJing, LiChun-mei*. Preparation of A-type proanthocyanidin dimers from peanutskins and persimmon pulp and comparison of the antioxidantactivity of A-type and B-type dimers[J]. Fitoterapia. 91:128-139, 2013
【专利】
1. 李春美; 王玥; 李凯凯; 杨明美; 邓祥宜, 一种柿果乳酸菌发酵果汁饮料制备方法, 专利申请号：2017010601.324390
2. 李春美; 杜静; 葛珍珍; 徐泽; 朱维,一种柿子全果低温喷雾干燥粉及其制备方法，专利授权号：ZL2014101900840.9
3 李春美; 杨立; 邹波; 杜静, 一种抗氧化补钙鱼鳞肽钙复合咀嚼片及其制备方法,专利授权号：ZL201210010943.3
4.李春美，万琼红，熊善柏，钟朝晖，党美珠.从淡水鱼鱼鳞中制备未变性胶原蛋白的方法， ZL200810048018.3
【科技奖励和鉴定成果】
1. 李春美(3/15),特色浆果的营养健康效应及其精深加工关键技术研究与应用。广东省科技进步二等奖。2019，余元善，徐玉娟，李春美，邹波，江水泉，李斌，胡丽娜，谢涛，卜智斌，温靖，吴继军，林羡，傅曼琴，周波，刘家生。证书编号：J03-1-03-R03
2. 李春美(6/24), 华南特色水果综合加工关键技术及产业化, 中华人民共和国农业部, 科技进步, 省部二等奖, 2017.11.17(徐玉娟; 肖更生; 吴继军; 余元善; 唐道邦; 李春美; 温靖; 张岩; 陈卫东; 宁进辉;李兴斌; 林羡; 陈于陇; 李俊; 黄盛锋; 卫高利; 张友胜; 刘子放; 李升锋; 刘学铭;傅曼琴; 邹波; 安可婧; 姚锡镇；证书编号：KJ2017-R2-033-06
3. 李春美(6/24), 岭南大宗水果综合加工关键技术及产业化应用, 广东省科技进步二等奖B03-1-01-R06
4. 李春美，杜静，李凯凯. “柿果全粉高效制备关键技术研究”，通过湖北省科技厅组织的成果鉴定，鉴定结果：国际先进；2017.1

其它

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